Mostly we work with targeted therapies that block (at various stages) gene expression -- some are antiangiogenics (they prevent new blood vessels from forming), some inhibit the expression of certain proteins or kinases, which eventually leads to tumor cell death. I don't think any of the ones we're working on right now cause DNA methylation or chromatin remodeling, which is what epigenetic treatments are based on. Is he having any luck finding treatments?
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Date: 2008-10-12 05:35 pm (UTC)